Total synthesis of (+)-sundiversifolide

Org Lett. 2007 Mar 15;9(6):969-71. doi: 10.1021/ol062960h. Epub 2007 Feb 13.

Abstract

The first, enantiocontrolled total synthesis of (+)-sundiversifolide has been accomplished using the sequential ring-closing metathesis, [3,3]-sigmatropic rearrangement, and iodolactonization for the key assembly of the cis-fused oxabicyclo[5.3.0]decene framework of the natural product. [structure: see text]

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemical synthesis*
  • Bridged Bicyclo Compounds / chemistry
  • Bridged-Ring Compounds / chemistry
  • Cyclization
  • Lactones / chemistry
  • Models, Chemical
  • Stereoisomerism
  • Xanthenes / chemical synthesis*

Substances

  • Biological Products
  • Bridged Bicyclo Compounds
  • Bridged-Ring Compounds
  • Lactones
  • Xanthenes
  • bicyclo(5.3.0)decane
  • sundiversifolide