Botulinum toxin for post-stroke spastic hypertonia: a review of its efficacy and application in clinical practice

Ann Acad Med Singap. 2007 Jan;36(1):22-30.

Abstract

Botulinum toxins (BTX) have revolutionised the management of focal post-stroke spastic hypertonia. Published literature has supported the efficacy and safety of BTX in reducing spastic hypertonia but has not convincingly demonstrated the ability to enhance function. While clinicians and stroke survivors have reported impressive clinical outcomes, randomised, controlled trials (RCTs), have demonstrated only significant improvement in muscle tone but not functional changes. This paper will review the evidence supporting the efficacy of BTX for spastic hypertonia and discuss current clinical practice.

Publication types

  • Review

MeSH terms

  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / therapeutic use*
  • Humans
  • Muscle Hypertonia / drug therapy*
  • Muscle Hypertonia / etiology
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / therapeutic use*
  • Recovery of Function
  • Stroke / complications
  • Treatment Outcome

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A