Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia

Dong-Qing Fei; Shi-Gang Li; Chun-Mei Liu; Gang Wu; Kun Gao

doi:10.1021/np060304k

Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia

J Nat Prod. 2007 Feb;70(2):241-5. doi: 10.1021/np060304k. Epub 2007 Feb 7.

Authors

Dong-Qing Fei¹, Shi-Gang Li, Chun-Mei Liu, Gang Wu, Kun Gao

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.

PMID: 17284071
DOI: 10.1021/np060304k

Abstract

Six new highly oxygenated eremophilane-type sesquiterpene derivatives (1-6), including a norbisesquiterpene, were isolated from an extract of the roots of Ligularia lapathifolia, and their structures were elucidated by spectroscopic methods. The structure of 1 was confirmed by single-crystal X-ray crystallography. In addition, the cytotoxicity of compounds 1, 2, 3, 5, and 6 was evaluated against selected cancer cell lines, including human stomach carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Asteraceae / chemistry*
China
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Molecular Structure
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Sesquiterpenes / chemistry*
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Sesquiterpenes