Probabilistic control of gene networks

Peter Y Chen; Jeremy Chen

doi:10.1109/IEMBS.2005.1617096

Probabilistic control of gene networks

Conf Proc IEEE Eng Med Biol Soc. 2005:2005:2966-70. doi: 10.1109/IEMBS.2005.1617096.

Authors

Peter Y Chen¹, Jeremy Chen

Affiliation

¹ Bachelor of Tech. Programme, Nat. Univ. of Singapore.

PMID: 17282865
DOI: 10.1109/IEMBS.2005.1617096

Abstract

In this paper, an approach based on Markov chains for controlling gene networks is proposed. The state of the network is represented as a probability distribution, while state transitions are considered to be probabilistic. An algorithm is proposed to determine a sequence of control actions that drives the state of a given network to within a desired state set with a prescribed minimum or maximum probability. A heuristic is proposed and shown to improve the efficiency of the proposed algorithm for a class of gene networks.