This paper presents the upgrading of biomedical engineering laboratory training at the Department of Medical Instrumentation Technology of the Technological Educational Institution of Athens (TEI-A), taking place in the framework of the "Upgrading of Undergraduate Curricula of TEI-A" project. The educational material of selected specialized laboratory sectors is totally renewed, and new sectors are introduced, so that student-centered learning is promoted utilizing advanced computer-enhanced educational environments. The current implementation status is presented for the laboratories dealing with biosignal acquisition, medical data digital processing and, more extensively, computer networks applications in medicine, where a training application simulating a Radiology Department computer network was developed. Benefits of the use of a balanced training approach, combining hands-on experience with computer simulations, are discussed.