Nonlinear analysis in treatment of intractable epilepsy with EEG biofeedback

Longlian Zhao; Zuoqing Liang; Guangshu Hu; Wenqing Wu

doi:10.1109/IEMBS.2005.1615486

Nonlinear analysis in treatment of intractable epilepsy with EEG biofeedback

Conf Proc IEEE Eng Med Biol Soc. 2005:2005:4568-71. doi: 10.1109/IEMBS.2005.1615486.

Authors

Longlian Zhao¹, Zuoqing Liang, Guangshu Hu, Wenqing Wu

Affiliation

¹ Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China.

PMID: 17281256
DOI: 10.1109/IEMBS.2005.1615486

Abstract

About 25% epilepsy patients are suffering from medically intractable epileptic seizure. Many studies have shown that electroencephalogram (EEG) biofeedback therapy has the exciting potential for seizure control. In this paper, five patients with intractable epilepsy were trained to increase the production of sensorimotor (12~15Hz) activity and decrease the production of slow theta (4~7Hz) activity. Nonlinear analysis are proposed to evaluate the effect of biofeedback training. In all the five patients, the complexity and approximate entropy of EEG increased significantly (P<0.05) after (about 1-month) the biofeedback treatment.