The purpose of this study is to develop a M3S- Based GPS navigation system for power wheelchair. The wheelchair steered with GPS and electronic compass can move automatically toward a specific destination through a GIS-Map in the computer. The topic of this study is to help people with disabilities regain independence of transportation in specific areas of their daily activities. This system is now designed to operate in special locations, for example, campuses or airports. Safety of the system is enhanced according to "M3S", which is an international standard for power wheelchair. In the proposed architecture, modules are easily and securely integrated to the wheelchair, which includes a tele-monitor system implemented with computer network, mobile-phone and physiological sensors. Bio-signals, wheelchair location and other information of the user are acquired by the nursing staff or any other medical personnel by using this system.