Bubble statistics and dynamics in double-stranded DNA

Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Nov;74(5 Pt 1):050901. doi: 10.1103/PhysRevE.74.050901. Epub 2006 Nov 1.

Abstract

The dynamical properties of double-stranded DNA are studied in the framework of the Peyrard-Bishop-Dauxois model using Langevin dynamics. Our simulations are analyzed in terms of two distribution functions describing localized separations ("bubbles") of the double strand. The result that the bubble distributions are more sharply peaked at the active sites than thermodynamically obtained distributions is ascribed to the fact that the bubble lifetimes affect the distributions. Certain base-pair sequences are found to promote long-lived bubbles, and we argue that this is a result of length scale competition between the nonlinearity and disorder present in the system.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Computer Simulation
  • DNA / chemistry*
  • DNA / ultrastructure*
  • Models, Chemical*
  • Models, Molecular*
  • Models, Statistical
  • Nucleic Acid Conformation
  • Nucleotides / chemistry*
  • Temperature

Substances

  • Nucleotides
  • DNA