Iron-sulfur cluster stability. Kinetics and mechanism of ligand-promoted cluster degradation

Chem Commun (Camb). 2007 Jan 7:(1):82-4. doi: 10.1039/b610665j. Epub 2006 Oct 18.

Abstract

Reactivity studies of iron-sulfur cluster proteins with chelating ligands model the reactivity of cluster scaffold proteins such as ISU, and suggest a rate law [k(obs) = k2[ligand]n/{[ligand]n + K(D)}] consistent with formation of a pre-reaction complex between the Fe-S protein and one chelate ligand.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt / chemistry
  • 2,2'-Dipyridyl / chemistry
  • Amino Acid Substitution
  • Chelating Agents / chemistry*
  • Ferredoxins / chemistry
  • Humans
  • Iron / chemistry
  • Iron-Sulfur Proteins / chemistry*
  • Iron-Sulfur Proteins / genetics
  • Kinetics
  • Ligands
  • Schizosaccharomyces / chemistry
  • Spectrophotometry
  • Spectrophotometry, Ultraviolet

Substances

  • Chelating Agents
  • Ferredoxins
  • Iron-Sulfur Proteins
  • Ligands
  • 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
  • 2,2'-Dipyridyl
  • Iron