Abstract
Reactivity studies of iron-sulfur cluster proteins with chelating ligands model the reactivity of cluster scaffold proteins such as ISU, and suggest a rate law [k(obs) = k2[ligand]n/{[ligand]n + K(D)}] consistent with formation of a pre-reaction complex between the Fe-S protein and one chelate ligand.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt / chemistry
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2,2'-Dipyridyl / chemistry
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Amino Acid Substitution
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Chelating Agents / chemistry*
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Ferredoxins / chemistry
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Humans
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Iron / chemistry
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Iron-Sulfur Proteins / chemistry*
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Iron-Sulfur Proteins / genetics
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Kinetics
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Ligands
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Schizosaccharomyces / chemistry
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Spectrophotometry
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Spectrophotometry, Ultraviolet
Substances
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Chelating Agents
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Ferredoxins
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Iron-Sulfur Proteins
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Ligands
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1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
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2,2'-Dipyridyl
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Iron