Chemistry and biology of resorcylic acid lactones

Chem Commun (Camb). 2007 Jan 7:(1):22-36. doi: 10.1039/b610344h. Epub 2006 Sep 25.

Abstract

While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

Publication types

  • Review

MeSH terms

  • HSP90 Heat-Shock Proteins / antagonists & inhibitors
  • Hydroxybenzoates / chemistry*
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Lactones / pharmacology
  • Macrocyclic Compounds / chemical synthesis
  • Macrocyclic Compounds / chemistry
  • Macrocyclic Compounds / pharmacology
  • Macrolides / chemical synthesis
  • Macrolides / chemistry
  • Macrolides / pharmacology
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Molecular Structure
  • Mycotoxins / chemical synthesis*
  • Mycotoxins / chemistry
  • Mycotoxins / pharmacology
  • Zearalenone / analogs & derivatives
  • Zearalenone / chemical synthesis
  • Zearalenone / chemistry
  • Zearalenone / pharmacology

Substances

  • HSP90 Heat-Shock Proteins
  • Hydroxybenzoates
  • LL Z1640-2
  • Lactones
  • Macrocyclic Compounds
  • Macrolides
  • Mycotoxins
  • hypothemycin
  • Zearalenone
  • Mitogen-Activated Protein Kinases
  • monorden
  • beta-resorcylic acid