Breast cancer in the elderly: histological, hormonal and surgical characteristics

Breast. 2007 Feb;16(1):60-7. doi: 10.1016/j.breast.2006.05.007.

Abstract

The characteristics, menstrual risk factors and surgical therapy of 187 consecutive patients more than 70 years of age (mean: 75.9) were investigated and compared with those of 609 patients less than 70 years of age (mean: 53.9). There was no difference in stage, size, state of axillary nodes, grade, histological types, Ki-67, vascular invasion, estrogen receptor rate, and HER-2/neu (+) rate. Positive progesterone receptor rate was higher in older patients (54.7% vs. 63.1%). Tumors were larger (p=0.01) and their stage higher (p=0.014) in patients more than 80 years of age. All menstrual risk factors were similar in the two groups. Positive familial history was more frequent in patients <60 years. Significantly more young patients used hormone replacement therapy (HRT) (21.8 vs. 8.6%). Older patients underwent less breast-conserving surgery (36.1 vs. 55.1%), and less axillary lymph node dissection (ALND) (69.7 vs. 84.9%). We conclude that breast cancer characteristics and menstrual risk factors are similar in the two age groups.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / physiopathology
  • Breast Neoplasms / surgery
  • Estrogen Replacement Therapy / statistics & numerical data
  • Humans
  • Israel / epidemiology
  • Lymph Node Excision / statistics & numerical data
  • Mastectomy, Segmental / statistics & numerical data
  • Menarche
  • Middle Aged
  • Retrospective Studies
  • Risk Factors