Abstract
The anti-diarrheal activity of methanol extract of dried bark and aerial parts of Litsea polyantha (MELP) has been evaluated in mice using different models (castor oil-induced diarrhea and propulsive gut motility in mice). MELP (50, 75, 100 mg/kg, p.o.) significantly (P<0.01) reduced the onset of diarrhea, fecal excretion and also showed a significant (P<0.001) reduction in gastrointestinal motility on charcoal meal test in mice. The results of the study support the folklore use of the plant for diarrheal remedies.
MeSH terms
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Administration, Oral
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Animals
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Antidiarrheals / administration & dosage
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Antidiarrheals / pharmacology*
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Antidiarrheals / therapeutic use
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Castor Oil
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Diarrhea / chemically induced
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Diarrhea / prevention & control*
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Dose-Response Relationship, Drug
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Female
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Gastrointestinal Motility / drug effects*
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Litsea*
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Male
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Mice
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Phytotherapy*
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Plant Bark
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Plant Components, Aerial
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
Substances
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Antidiarrheals
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Plant Extracts
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Castor Oil