Optimal glucose-insulin control in H2 space

L Kovács; B Paláncz; Zs Almássy; Z Benyó

doi:10.1109/IEMBS.2004.1403270

Optimal glucose-insulin control in H2 space

Conf Proc IEEE Eng Med Biol Soc. 2004:2006:762-5. doi: 10.1109/IEMBS.2004.1403270.

Authors

L Kovács¹, B Paláncz, Zs Almássy, Z Benyó

Affiliation

¹ Dep. of Control Eng. & Inf. Technol., Budapest Univ. of Technol. & Econ., Hungary.

PMID: 17271789
DOI: 10.1109/IEMBS.2004.1403270

Abstract

In this case study optimal glucose-insulin control in the Hardy H/sub 2/-space is presented for diabetic patients under intensive care. The analysis is based on a modified two-compartment model. First the classical LQ optimal control design method is considered, and then its extension the so called disturbance rejection LQR (LQ rejection) method, based on the MINIMAX differential game is applied to control design. To demonstrate the results of these two methods, the simulation of the dynamical performance of the non-linear closed loop system in case of food (sugar) intake has been carried out. For the symbolic and numeric computations Mathematica and Matlab-Simulink are used.