Circulating human monocytes in the acute coronary syndrome express a characteristic proteomic profile

J Proteome Res. 2007 Feb;6(2):876-86. doi: 10.1021/pr0601990.

Abstract

We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed progressively, and at 6 months, there were no differences with the monocyte proteome of stable patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Proteins / metabolism*
  • Coronary Angiography
  • Coronary Disease / blood*
  • Coronary Disease / diagnostic imaging
  • Enzymes / blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Monocytes / pathology*
  • Patient Selection
  • Proteomics / methods*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Blood Proteins
  • Enzymes