Abstract
The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology*
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Glucosyltransferases / antagonists & inhibitors*
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Humans
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Imino Sugars / chemistry*
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Imino Sugars / pharmacology*
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Imino Sugars
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Glucosyltransferases
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ceramide glucosyltransferase