Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models

Yakugaku Zasshi. 2007 Feb;127(2):359-65. doi: 10.1248/yakushi.127.359.

Abstract

The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p < 0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / isolation & purification*
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / therapeutic use*
  • Chloroform*
  • Corchorus / chemistry*
  • Edema / prevention & control*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Models, Animal
  • Pain / prevention & control*
  • Phytotherapy*
  • Plant Extracts / isolation & purification*
  • Plant Extracts / therapeutic use*
  • Plant Leaves / chemistry*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Chloroform