Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs

S N Shchelkunov; S B Stavitskii; L I Batenko; P V Gashnikov; G A Shchelkunova; O A Kostyrev; L S Sandakhchiev

Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs

Biomed Sci. 1991;2(5):493-7.

Authors

S N Shchelkunov¹, S B Stavitskii, L I Batenko, P V Gashnikov, G A Shchelkunova, O A Kostyrev, L S Sandakhchiev

Affiliation

¹ All-Union Research Institute of Molecular Biology, Novosibirsk region.

PMID: 1726719

Abstract

A hybrid vaccinia virus expressing a chimeric protein consisting of thymidine kinase and the encephalitogenic determinant, S1, from guinea pig myelin basic protein was constructed. Infection of guinea pigs with the virus resulted in the development of allergic encephalomyelitis.

MeSH terms

Animals
Base Sequence
Encephalomyelitis, Autoimmune, Experimental / microbiology*
Encephalomyelitis, Autoimmune, Experimental / pathology
Guinea Pigs
Molecular Sequence Data
Myelin Basic Protein / physiology*
Recombinant Proteins / chemistry
Thymidine Kinase / physiology*
Vaccinia virus / chemistry
Vaccinia virus / pathogenicity
Viral Proteins / chemistry
Viral Proteins / physiology*

Substances

Myelin Basic Protein
Recombinant Proteins
Viral Proteins
Thymidine Kinase