Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail

Neurosci Lett. 2007 Mar 26;415(2):102-7. doi: 10.1016/j.neulet.2007.01.007. Epub 2007 Jan 5.

Abstract

To investigate the physiological roles of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in avian species, we elucidated the effect of intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of GLP-1 and GLP-2 on food intake, body temperature and gross locomotor activity in adult Japanese quail. Both i.p. and i.c.v. administration of GLP-1 suppressed food intake at 2, 4 and 12h after administration. Moreover, both i.p. and i.c.v. administration of GLP-1 significantly decreased both body temperature and gross locomotor activity 2h after administration. On the other hand, both i.p. and i.c.v. administration of GLP-2 had no effect on food intake, body temperature or gross locomotor activity. These results suggest that GLP-1 may have an important role in the regulation of food intake, body temperature and locomotor activity while GLP-2 may have no apparent effect on feeding regulation in adult Japanese quail.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Behavior, Animal / drug effects
  • Body Temperature / drug effects*
  • Coturnix / physiology
  • Dose-Response Relationship, Drug
  • Eating / drug effects*
  • Glucagon-Like Peptide 1 / pharmacology*
  • Glucagon-Like Peptide 2 / pharmacology*
  • Male
  • Motor Activity / drug effects*
  • Time Factors

Substances

  • Glucagon-Like Peptide 2
  • Glucagon-Like Peptide 1