This study aimed at the assessment of the nurses' knowledge and attitudes towards epilepsy. A sample consisting of 273 nurses working in different hospital departments, at three University hospitals in Tanta, Menoufiya and Zagazig was chosen. The results revealed a deficiency in the nurses' knowledge about epilepsy. However, they had a moderately positive attitude towards epilepsy. Although more than half of them considered epilepsy a mental illness, they agreed that epileptics must learn in special schools. It is recommended that all in-service training programs for nurses should emphasize epilepsy management, rehabilitation of epileptics, and how to change public attitudes towards epilepsy.