Bacterial infections of the cornea (Pseudomonas aeruginosa)

Abstract

Pseudomonas aeruginosa is a common organism associated with bacterial keratitis, especially in extended wear contact lens users. Recent advances in the field have been made using animal models, including inbred murine models that are classed as resistant (cornea heals) versus susceptible (cornea perforates). Overall, studies with these inbred mice provide a better understanding of the mechanisms of innate immune responsiveness and abrogation of immune privilege operative after P. aeruginosa corneal infection.