Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia

Antimicrob Agents Chemother. 2007 Apr;51(4):1573-6. doi: 10.1128/AAC.01038-06. Epub 2007 Jan 29.

Abstract

In vitro susceptibility of 58 isolates of Pichia anomala to five antifungal drugs using two broth microdilution methods (CLSI and EUCAST) was analyzed. Low susceptibility to itraconazole was observed. Fluconazole, voriconazole, amphotericin B, and caspofungin showed good antifungal activity, although relatively high drug concentrations were necessary to inhibit the isolates.

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Cross Infection / microbiology*
  • Fluconazole / pharmacology
  • Fungemia / epidemiology
  • Fungemia / microbiology*
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests / methods*
  • Pichia / drug effects*
  • Pichia / isolation & purification

Substances

  • Antifungal Agents
  • Itraconazole
  • Amphotericin B
  • Fluconazole