P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis

Chem Biodivers. 2007 Jan;4(1):12-6. doi: 10.1002/cbdv.200790001.

Abstract

(-)-Syringaresinol and tricin, isolated from the AcOEt-soluble extract of the whole plants of Sasa borealis (Gramineae), showed inhibitory effects on the P-glycoprotein in adriamycin-resistant human breast cancer cells, MCF-7/ADR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Bambusa / chemistry*
  • Cell Line, Tumor
  • Chromatography, Thin Layer
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology*
  • Furans / isolation & purification
  • Furans / pharmacology*
  • Humans
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Spectrum Analysis

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Flavonoids
  • Furans
  • Lignans
  • syringaresinol
  • tricin