Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine

AIDS. 2007 Jan 30;21(3):375-7. doi: 10.1097/QAD.0b013e328012b873.

Abstract

Antibody responses against human leukocyte antigen (HLA) classes I and II were detected in HIV-1 infected individuals who received a fixed inactivated HIV-1 (Remune) immunotherapy. The response was specific for HLA-B62 and HLA-DR4 concordant with the host cell line, HUT-78, used in vaccine production. These responses were not detected in HLA-B62 and HLA-DR4-positive individuals indicating that immunotherapy did not break tolerance to self-antigens.

Publication types

  • Clinical Trial, Phase I
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines / immunology*
  • Antibody Specificity
  • Antiretroviral Therapy, Highly Active
  • HIV-1*
  • HLA Antigens / immunology*
  • Histocompatibility Testing
  • Humans
  • Isoantibodies / biosynthesis*
  • Male
  • Vaccines, Inactivated / immunology

Substances

  • AIDS Vaccines
  • HLA Antigens
  • Isoantibodies
  • Vaccines, Inactivated
  • remune