Oncogene-induced senescence pathways weave an intricate tapestry

Cell. 2007 Jan 26;128(2):233-4. doi: 10.1016/j.cell.2007.01.005.

Abstract

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / metabolism
  • Cellular Senescence / genetics*
  • DNA Damage / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Oncogenes / genetics*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction / genetics
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Tumor Suppressor Protein p53
  • MAP-kinase-activated kinase 5
  • Protein Serine-Threonine Kinases