Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages

Nobuhiro Koyama; Taichi Ohshiro; Hiroshi Tomoda; Satoshi Omura

doi:10.1021/ol062722m

Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages

Org Lett. 2007 Feb 1;9(3):425-8. doi: 10.1021/ol062722m.

Authors

Nobuhiro Koyama¹, Taichi Ohshiro, Hiroshi Tomoda, Satoshi Omura

Affiliation

¹ School of Pharmacy, Kitasato University, Kitasato Institute for Life Sciences, Kitasato University, and the Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

PMID: 17249778
DOI: 10.1021/ol062722m

Abstract

[structure: see text] New isobisvertinol and known bisvertinol were isolated from the culture broth of Aspergillus sp. FKI-1746. Isobisvertinol with the two alkenyl side chains extending in the same direction inhibited lipid droplet accumulation in macrophages, whereas bisvertinol with those extending in the reverse direction had almost no effect on the accumulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry
Alkenes / isolation & purification
Alkenes / pharmacology*
Animals
Aspergillus / chemistry*
Heterocyclic Compounds, 3-Ring / chemistry
Heterocyclic Compounds, 3-Ring / isolation & purification
Heterocyclic Compounds, 3-Ring / pharmacology*
Hypolipidemic Agents / pharmacology*
Lipid Metabolism / drug effects*
Macrophages / drug effects*
Macrophages / metabolism
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Models, Molecular

Substances

Alkenes
Heterocyclic Compounds, 3-Ring
Hypolipidemic Agents
bisvertinol
isobisvertinol