Controlling multiple fluorescent signal output in cyclic peptide-based supramolecular systems

J Am Chem Soc. 2007 Feb 14;129(6):1653-7. doi: 10.1021/ja066885h. Epub 2007 Jan 23.

Abstract

A multicomponent equilibrium network based on self-assembling alpha,gamma-cyclic peptides with controlled fluorescence output is described. The network takes advantage of the large association constant of alpha,gamma-cyclic peptides and the controlled formation homo- and heterodimers, making use for the first time of excimer/FRET effects in conjunction for studying complex interaction networks. In addition, we study the Dapoxyl/pyrene FRET pair for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Cyclic / chemistry
  • Cyclohexanecarboxylic Acids / chemistry
  • Cyclopentanes / chemistry
  • Dimerization
  • Fluorescence Resonance Energy Transfer
  • Models, Molecular
  • Peptides, Cyclic / chemistry*
  • Pyrenes / chemistry
  • Spectrometry, Fluorescence / methods

Substances

  • Amino Acids, Cyclic
  • Cyclohexanecarboxylic Acids
  • Cyclopentanes
  • Peptides, Cyclic
  • Pyrenes
  • 3-aminocyclohexanecarboxylic acid
  • 3-aminocyclopentane-1-carboxylic acid
  • pyrene