Abstract
A multicomponent equilibrium network based on self-assembling alpha,gamma-cyclic peptides with controlled fluorescence output is described. The network takes advantage of the large association constant of alpha,gamma-cyclic peptides and the controlled formation homo- and heterodimers, making use for the first time of excimer/FRET effects in conjunction for studying complex interaction networks. In addition, we study the Dapoxyl/pyrene FRET pair for the first time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids, Cyclic / chemistry
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Cyclohexanecarboxylic Acids / chemistry
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Cyclopentanes / chemistry
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Dimerization
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Fluorescence Resonance Energy Transfer
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Models, Molecular
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Peptides, Cyclic / chemistry*
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Pyrenes / chemistry
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Spectrometry, Fluorescence / methods
Substances
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Amino Acids, Cyclic
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Cyclohexanecarboxylic Acids
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Cyclopentanes
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Peptides, Cyclic
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Pyrenes
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3-aminocyclohexanecarboxylic acid
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3-aminocyclopentane-1-carboxylic acid
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pyrene