The application of Botulinum toxin has become a useful and significant tool for oral and maxillofacial lesions. The art of using Botulinum toxin, a technical procedure, is influenced by aesthetic judgement and applications that extend beyond its use of reducing wrinkles to improve facial forms and shape. Novel uses for this unique substance will continue to permeate many medical and surgical specialties. Botulinum toxin delivered using more precise techniques may permit improved results without undesired consequences.