To evaluate the importance of follicular flushing on semi natural cycles IVF, we have compared prospectively the reproductive potential of oocytes obtained from follicular fluid (group A, n = 79) to those obtained from follicular flushing (group B, n = 47) in 146 oocyte pick-ups. The groups A and B were similar on the fertilisation rate (79.7% versus 88.1%, respectively), percentage of superior grade embryos (28.8% versus 37.8%) and the implantation rate (24.1% versus 44.1%) and 53.6% of total clinical pregnancies were obtained from group B. The practice of follicular flushing on IVF semi natural cycle improves the pregnancy rate. The oocytes obtained by follicular flushing had the same reproductive potential than those obtained on follicular fluid.