Mupirocin resistance in Staphylococcus aureus in an Indian hospital

Ravisekhar Gadepalli; Benu Dhawan; Srujana Mohanty; Arti Kapil; Bimal K Das; Rama Chaudhry; J C Samantaray

doi:10.1016/j.diagmicrobio.2006.10.012

Mupirocin resistance in Staphylococcus aureus in an Indian hospital

Diagn Microbiol Infect Dis. 2007 May;58(1):125-7. doi: 10.1016/j.diagmicrobio.2006.10.012. Epub 2007 Jan 19.

Authors

Ravisekhar Gadepalli¹, Benu Dhawan, Srujana Mohanty, Arti Kapil, Bimal K Das, Rama Chaudhry, J C Samantaray

Affiliation

¹ Department of Microbiology, All India Institute of Medical Sciences, New Delhi-29, India.

PMID: 17240103
DOI: 10.1016/j.diagmicrobio.2006.10.012

Abstract

Two hundred Staphylococcus aureus strains collected from an Indian hospital were tested for mupirocin susceptibility using disc diffusion method and E-test. High-level and low-level mupirocin resistance was detected in 10 (5%) and 2 (1%) S. aureus strains, respectively. Pulsed-field gel electrophoresis analysis of the high-level mupirocin-resistant methicillin-resistant S. aureus isolates revealed the presence of 2 clones with the majority of strains belonging to 1 clone, suggesting clonal dissemination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics
Drug Resistance, Bacterial* / genetics
Electrophoresis, Gel, Pulsed-Field
Genotype
Hospitals*
Humans
India / epidemiology
Methicillin Resistance / genetics
Microbial Sensitivity Tests / methods
Mupirocin / pharmacology*
Polymerase Chain Reaction
Staphylococcal Infections / epidemiology*
Staphylococcal Infections / microbiology
Staphylococcus aureus / classification
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics

Substances

Anti-Bacterial Agents
Bacterial Proteins
Mupirocin