Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?

Pediatr Transplant. 2007 Feb;11(1):113-6. doi: 10.1111/j.1399-3046.2006.00622.x.

Abstract

We describe a case of Cryptosporidium infection occurring in a child after allogeneic SCT for acute non-lymphoblastic leukemia. This patient presented an intestinal, biliar, and pancreatic Cryptosporidium disease associated with an intestinal aGvHD. The increase in CD3+/CD4+ cells secondary to the reduction of steroid therapy associated with the improvement of aGvHD and the use of antiparasitic treatments (especially nitazoxanide) improved the infection-related symptoms and led to a complete clearance of the Cryptosporidium.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / blood
  • Antiparasitic Agents / therapeutic use*
  • Biopsy
  • CD3 Complex / blood
  • CD4-Positive T-Lymphocytes / transplantation
  • Child
  • Colon / parasitology
  • Colon / pathology
  • Cryptosporidiosis / drug therapy
  • Cryptosporidiosis / therapy*
  • Cryptosporidium / isolation & purification
  • Humans
  • Leukemia, Myeloid, Acute / therapy*
  • Lymphocyte Transfusion*
  • Male
  • Nitro Compounds
  • Stem Cell Transplantation*
  • Thiazoles / therapeutic use*
  • Transplantation, Homologous

Substances

  • Antigens, CD
  • Antiparasitic Agents
  • CD3 Complex
  • Nitro Compounds
  • Thiazoles
  • nitazoxanide