Nanotechnology is an important, rapidly-evolving, multidisciplinary field. The tremendous growth in this area necessitates the establishment of a common, open-source terminology to support the diverse biomedical applications of nanotechnology. Currently, the consensus process to define and categorize conceptual entities pertaining to nanotechnology is in a rudimentary stage. We have constructed a nanotechnology-specific conceptual hierarchy that can be utilized by end users to retrieve accurate, controlled terminology regarding emerging nanotechnology and corresponding clinical applications.