Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis

Cell Death Differ. 2007 May;14(5):1060-2. doi: 10.1038/sj.cdd.4402095. Epub 2007 Jan 19.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • Blood Pressure
  • Cardiac Output, Low / chemically induced
  • Cardiac Output, Low / pathology
  • Cardiac Output, Low / physiopathology
  • Cardiac Output, Low / prevention & control*
  • Coronary Circulation
  • Gene Expression Regulation
  • Glutamic Acid / genetics*
  • Lysine / genetics*
  • Mice
  • Myocardium / enzymology*
  • Myocardium / pathology
  • Myocytes, Cardiac / pathology
  • Neovascularization, Physiologic*
  • Proto-Oncogene Proteins c-akt / chemistry
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • RNA, Messenger
  • Vascular Endothelial Growth Factor A
  • Glutamic Acid
  • Proto-Oncogene Proteins c-akt
  • Lysine