Abstract
A patient with multiple myeloma (MM) was being maintained on human recombinant interferon-alpha (INF-alpha) after VAD and autologous bone marrow transplantation (pretreated with melphalan). An episode of immune thrombocytopenia and (Coombs positive) autoimmune hemolytic anemia (AIHA) was noted while on maintenance INF-alpha, which remitted when it was withdrawn. Following this event, he achieved a state of stable disease that persists (more than 3 years) with no specific myeloma treatment. This sequence of events suggests a relationship between an immunological reaction induced by INF-alpha and the prolonged phase of stable disease.
(c) 2007 Wiley-Liss, Inc.
MeSH terms
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Anemia, Hemolytic, Autoimmune / diagnosis
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Anemia, Hemolytic, Autoimmune / immunology
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Anemia, Hemolytic, Autoimmune / therapy*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow Transplantation / methods
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Follow-Up Studies
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Humans
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Interferon Type I / therapeutic use*
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Male
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Middle Aged
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Multiple Myeloma / diagnosis
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Multiple Myeloma / immunology
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Multiple Myeloma / therapy*
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Purpura, Thrombocytopenic, Idiopathic / diagnosis
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Purpura, Thrombocytopenic, Idiopathic / immunology
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Purpura, Thrombocytopenic, Idiopathic / therapy
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Recombinant Proteins
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Remission Induction
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Transplantation, Autologous
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Treatment Outcome
Substances
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Interferon Type I
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Recombinant Proteins