Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy

Cancer Res. 2007 Jan 15;67(2):433-6. doi: 10.1158/0008-5472.CAN-06-3114.

Abstract

The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Female
  • Humans
  • Mucin-4
  • Mucins / metabolism*
  • Neoplasm Metastasis
  • Neoplasms / diagnosis
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / therapy
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy

Substances

  • Biomarkers, Tumor
  • MUC4 protein, human
  • Mucin-4
  • Mucins