Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease

Tiina M Kauppinen

doi:10.1016/j.neuint.2006.11.010

Multiple roles for poly(ADP-ribose)polymerase-1 in neurological disease

Neurochem Int. 2007 Jun;50(7-8):954-8. doi: 10.1016/j.neuint.2006.11.010. Epub 2007 Jan 12.

Author

Tiina M Kauppinen¹

Affiliation

¹ Department of Neurology, University of California at San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. Tiina.Kauppinen@ucsf.edu

PMID: 17222947
DOI: 10.1016/j.neuint.2006.11.010

Abstract

Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has peaked. This review introduces mechanism of PARP-1 activation, the role of PARP-1 in cell physiology and pathology, and discusses the potential of PARP-1 inhibition as a therapy in acute and chronic CNS diseases.

Publication types

Review

MeSH terms

Brain Death
Central Nervous System Diseases / enzymology*
Central Nervous System Diseases / genetics
Central Nervous System Diseases / pathology
DNA Repair*
Enzyme Inhibitors / therapeutic use
Humans
Inflammation
Nervous System Diseases / enzymology*
Nervous System Diseases / genetics
Nervous System Diseases / pathology
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases / metabolism*

Substances

Enzyme Inhibitors
Poly(ADP-ribose) Polymerase Inhibitors
PARP1 protein, human
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases