Abstract
The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible beta-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proteins
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Blotting, Northern
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Cloning, Molecular
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DNA-Binding Proteins / genetics
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Escherichia coli / genetics*
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Escherichia coli / metabolism
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Fatty Acids / biosynthesis
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Fatty Acids / metabolism*
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Genes, Bacterial*
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RNA, Bacterial / genetics
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RNA, Bacterial / isolation & purification
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism
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Restriction Mapping
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Transcription, Genetic
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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FadR protein, Bacteria
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Fatty Acids
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RNA, Bacterial
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Repressor Proteins