Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation

J Mol Biol. 1991 Dec 20;222(4):843-9. doi: 10.1016/0022-2836(91)90574-p.

Abstract

The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible beta-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Proteins
  • Blotting, Northern
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics
  • Escherichia coli / genetics*
  • Escherichia coli / metabolism
  • Fatty Acids / biosynthesis
  • Fatty Acids / metabolism*
  • Genes, Bacterial*
  • RNA, Bacterial / genetics
  • RNA, Bacterial / isolation & purification
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Restriction Mapping
  • Transcription, Genetic

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • FadR protein, Bacteria
  • Fatty Acids
  • RNA, Bacterial
  • Repressor Proteins