In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci

Antimicrob Agents Chemother. 2007 Apr;51(4):1494-6. doi: 10.1128/AAC.00666-06. Epub 2007 Jan 12.

Abstract

This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Antimicrobial Cationic Peptides / metabolism
  • Antimicrobial Cationic Peptides / pharmacology*
  • Antimicrobial Cationic Peptides / therapeutic use
  • Cross Infection / drug therapy
  • Drug Synergism
  • Drug Therapy, Combination
  • Gram-Positive Cocci / drug effects*
  • Gram-Positive Cocci / metabolism
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • aurein 1.2 peptide