Abstract
This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Antimicrobial Cationic Peptides / metabolism
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Antimicrobial Cationic Peptides / pharmacology*
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Antimicrobial Cationic Peptides / therapeutic use
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Cross Infection / drug therapy
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Drug Synergism
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Drug Therapy, Combination
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Gram-Positive Cocci / drug effects*
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Gram-Positive Cocci / metabolism
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Antimicrobial Cationic Peptides
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aurein 1.2 peptide