Abstract
We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anthraquinones / pharmacology*
-
Anti-Bacterial Agents / pharmacology*
-
Biofilms / drug effects*
-
Biofilms / growth & development
-
Durapatite / metabolism
-
Microbial Sensitivity Tests
-
Streptococcus mutans / drug effects*
-
Streptococcus mutans / growth & development
-
Streptococcus mutans / metabolism
Substances
-
Anthraquinones
-
Anti-Bacterial Agents
-
Durapatite