Abstract
To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
MeSH terms
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Acetylcysteine / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Bacteria / growth & development
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Biofilms / drug effects*
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Biofilms / growth & development
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Catheterization, Central Venous
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Catheters, Indwelling / microbiology*
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Drug Combinations
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Drug Resistance, Bacterial / physiology
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Equipment Contamination / prevention & control*
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Minocycline / analogs & derivatives*
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Minocycline / pharmacology
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / growth & development
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Tigecycline
Substances
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Anti-Bacterial Agents
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Drug Combinations
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Tigecycline
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Minocycline
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Acetylcysteine