Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis

Adam J Potter; Stephen P Kidd; Michael P Jennings; Alastair G McEwan

doi:10.1128/IAI.01634-06

Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis

Infect Immun. 2007 Mar;75(3):1534-6. doi: 10.1128/IAI.01634-06. Epub 2007 Jan 12.

Authors

Adam J Potter¹, Stephen P Kidd, Michael P Jennings, Alastair G McEwan

Affiliation

¹ Australian Bacterial Pathogenesis Program, Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, Brisbane, QLD 4072, Australia.

Abstract

The adhC gene from 11 strains of Neisseria gonorrhoeae was distinguished from its homologue in Neisseria meningitidis by the presence of a premature stop codon caused by a single base insertion. Mutational analysis showed that NADH S-nitrosoglutathione oxidoreductase activity was associated with adhC in Neisseria meningitidis but not in Neisseria gonorrhoeae.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Oxidoreductases / genetics
Aldehyde Oxidoreductases / physiology*
Catalysis
Neisseria gonorrhoeae / enzymology*
Neisseria gonorrhoeae / genetics
Neisseria meningitidis / enzymology*
Neisseria meningitidis / genetics
S-Nitrosoglutathione / metabolism*

Substances

S-Nitrosoglutathione
formaldehyde dehydrogenase (glutathione)
Aldehyde Oxidoreductases