Comment on "A common genetic variant is associated with adult and childhood obesity"

Science. 2007 Jan 12;315(5809):187; author reply 187. doi: 10.1126/science.1130571.

Abstract

Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.

Publication types

  • Comment

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Body Mass Index*
  • Cross-Sectional Studies
  • Female
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Genotype
  • Germany
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / physiology
  • Male
  • Membrane Proteins / genetics*
  • Membrane Proteins / physiology
  • Middle Aged
  • Obesity / genetics*
  • Polymorphism, Single Nucleotide*

Substances

  • INSIG2 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins