Assembling a mixed phthalocyanine-porphyrin array in aqueous media through host-guest interactions

Org Lett. 2007 Jan 18;9(2):231-4. doi: 10.1021/ol0626645.

Abstract

A stable 1:1 host-guest complex is formed between a silicon(IV) phthalocyanine conjugated axially with two permethylated beta-cyclodextrin units and a tetrasulfonated porphyrin. The complex exhibits a light-harvesting property and works as an efficient photosensitizing system, killing HT29 human colon adenocarcinoma cells with an IC50 value of 0.09 microM. [structure: see text].

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Colonic Neoplasms / drug therapy*
  • Drug Screening Assays, Antitumor
  • Humans
  • Indoles / chemistry*
  • Indoles / radiation effects
  • Isoindoles
  • Light
  • Molecular Structure
  • Organosilicon Compounds / chemical synthesis*
  • Organosilicon Compounds / pharmacology
  • Organosilicon Compounds / radiation effects
  • Photochemotherapy / methods
  • Porphyrins / chemistry*
  • Porphyrins / radiation effects
  • Water / chemistry
  • beta-Cyclodextrins / chemistry
  • beta-Cyclodextrins / radiation effects

Substances

  • Indoles
  • Isoindoles
  • Organosilicon Compounds
  • Porphyrins
  • beta-Cyclodextrins
  • Water
  • betadex
  • phthalocyanine