Older adults with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and chronic depression constitute a growing population of individuals in need of quality nursing care management. Although the small amounts of research currently available focus on both middle-aged and older adults living with these chronic conditions, this article offers specific suggestions for the nursing care of older adults who have been diagnosed with HIV, have experienced the progression of HIV to AIDS, and who have lived with chronic depression prior to the onset of HIV/AIDS. Given the increasingly significant role that nurses play in the lives of older adults with chronic health conditions, this article aims to provide nurses with a number of interventions associated with 10 nursing diagnoses pertinent to the care of older adults with HIV/AIDS and chronic depression.