We reported an efficacy of percutaneous transhepatic portal embolization (PTPE) for three patients with hepatocellular carcinoma (HCC) who did not receive hepatic resection. All three patients, who had HCCs in the right hepatic lobe, were given transarterial chemoembolization (TACE) and PTPE in the aim of hepatic resection. However, hepatic resection was not performed because of the refusal of operation or insufficient hypertrophy of the remnant liver. Primary lesions were well controlled by TACE in all of the cases. We recognized new HCC lesions of the liver in the clinical courses, but all tumors appeared to be in the post-PTPE area only. A possibility of prevention for transportal intrahepatic dissemination by PTPE was considered. We conclude that combination therapy including PTPE for HCC patients with tumors in the limited area is useful for the improvement of their prognosis.