Objective: To observe the effect of DSF on NO System in experimental myocardial ischemia model by ligating the cornary descending branch.
Methods: Wistar mice were divided into control group, model group, Danshen group and DSF group to observe the effect of DSF on variations of the NO system.
Results: Compared with model group, content of NO, NOS and cNOS in serum and muscle in DSF group were significantly increased (P < 0.05 [Chinese character: see text] P < 0.01). But there was no statisical difference on the content of iNOS (P > 0.05) compared with model group. The expression of cNOS mRNA was increased (P < 0.05).
Conclusion: The mechanism of DSF in treating coronary is realized by improving the content of NO, the activity of NOS and expression of cNOS mRNA in myocardial tissue.