Abstract
We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, hippocampal neuron number, and spatial performance in the water maze. The bite-raised condition was associated with an accelerated age-related decline in spatial memory, increased plasma corticosterone levels, and a decreased number of neurons in the hippocampal CA3 region. The findings suggest that the bite-raised condition in aged SAMP8 mice induces hippocampal neuron loss, thereby leading to senile memory deficits.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aging / physiology
-
Aging / psychology
-
Animals
-
Cell Count
-
Cell Death / physiology
-
Corticosterone / blood
-
Hippocampus / pathology
-
Hippocampus / physiopathology*
-
Male
-
Malocclusion / complications*
-
Malocclusion / physiopathology
-
Malocclusion / psychology
-
Maze Learning / physiology
-
Memory Disorders / etiology*
-
Memory Disorders / physiopathology
-
Memory Disorders / psychology
-
Mice
-
Mice, Mutant Strains
-
Nerve Degeneration / etiology*
-
Nerve Degeneration / pathology
-
Nerve Degeneration / physiopathology
-
Stress, Psychological / complications*
-
Stress, Psychological / physiopathology
-
Temporomandibular Joint Disorders / complications
-
Temporomandibular Joint Disorders / physiopathology
-
Temporomandibular Joint Disorders / psychology
-
Up-Regulation / physiology