DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury

Gi-Wook Hwang; Akira Naganuma

doi:10.2131/jts.31.537

DNA microarray analysis of transcriptional responses of human neuroblastoma IMR-32 cells to methylmercury

J Toxicol Sci. 2006 Dec;31(5):537-8. doi: 10.2131/jts.31.537.

Authors

Gi-Wook Hwang¹, Akira Naganuma

Affiliation

¹ Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

PMID: 17202766
DOI: 10.2131/jts.31.537

Abstract

We used DNA microarrays to monitor the transcriptional responses of IMR-32 neuroblastoma cells to methylmercury. Methylmercury increased levels of expression of seven genes, including genes for ETV5 and ID4, and reduced those of two genes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Environmental Pollutants / toxicity*
Gene Expression Profiling
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Methylmercury Compounds / toxicity*
Neuroblastoma / genetics
Oligonucleotide Array Sequence Analysis

Substances

Environmental Pollutants
Methylmercury Compounds