Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia

Hisashi Matsuda; Sachiko Sugimoto; Toshio Morikawa; Koudai Matsuhira; Eri Mizuguchi; Seikou Nakamura; Masayuki Yoshikawa

doi:10.1248/cpb.55.106

Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia

Chem Pharm Bull (Tokyo). 2007 Jan;55(1):106-10. doi: 10.1248/cpb.55.106.

Authors

Hisashi Matsuda¹, Sachiko Sugimoto, Toshio Morikawa, Koudai Matsuhira, Eri Mizuguchi, Seikou Nakamura, Masayuki Yoshikawa

Affiliation

¹ Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.

PMID: 17202711
DOI: 10.1248/cpb.55.106

Abstract

The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of beta-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Delta(1),3-hydroxybakuchiol (IC(50) = 49 microM), Delta(3),2-hydroxybakuchiol (69 microM, bavachin (58 microM), and psoralidin (ca. 100 microM), showed inhibitory activities against the antigen-induced degranulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Degranulation / drug effects*
Cell Degranulation / immunology
Cell Line
Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Mass Spectrometry / methods
Medicine, Chinese Traditional*
Psoralea / chemistry*
Psoralea / embryology
Seeds / chemistry*
beta-N-Acetylhexosaminidases / antagonists & inhibitors
beta-N-Acetylhexosaminidases / metabolism

Substances

beta-N-Acetylhexosaminidases