Abstract
We successfully synthesized the potent and selective group II mGluR agonist (+)-1 (MGS0008) via a process incorporating the key step of efficient fluorination of epoxide (+/-)-5c. This method would be adaptable to large-scale synthesis to produce (+)-1 in multi-gram quantities.
MeSH terms
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Bridged Bicyclo Compounds
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Cyclohexanes / chemical synthesis*
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Cyclohexanes / pharmacology*
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Dicarboxylic Acids
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Excitatory Amino Acid Agonists / pharmacology*
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Magnetic Resonance Spectroscopy
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Receptors, Metabotropic Glutamate / agonists*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Bridged Bicyclo Compounds
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Cyclohexanes
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Dicarboxylic Acids
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Excitatory Amino Acid Agonists
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MGS 0008
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Receptors, Metabotropic Glutamate