Abstract
We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.
MeSH terms
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Adult
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Cholecalciferol / blood
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Chromosome Aberrations
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Diabetes Insipidus / complications*
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Diabetes Insipidus / diagnosis
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Diabetes Insipidus / metabolism
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Empty Sella Syndrome / chemically induced*
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Empty Sella Syndrome / diagnosis
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Empty Sella Syndrome / metabolism
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Female
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Humans
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Hypothalamic Diseases / complications*
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Hypothalamic Diseases / diagnosis
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Hypothalamic Diseases / metabolism
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Leukemia, Erythroblastic, Acute / complications*
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Leukemia, Erythroblastic, Acute / diagnosis
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Leukemia, Erythroblastic, Acute / metabolism
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MDS1 and EVI1 Complex Locus Protein
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Pituitary Gland / pathology*
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Proto-Oncogenes / genetics
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transforming Growth Factor beta1 / metabolism
Substances
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DNA-Binding Proteins
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MDS1 and EVI1 Complex Locus Protein
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MECOM protein, human
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Transcription Factors
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Transforming Growth Factor beta1
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Cholecalciferol