Erythroleukaemia, diabetes insipidus and hypophyseal damage: Two case reports

Leuk Res. 2007 Aug;31(8):1135-9. doi: 10.1016/j.leukres.2006.11.008. Epub 2007 Jan 2.

Abstract

We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cholecalciferol / blood
  • Chromosome Aberrations
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Diabetes Insipidus / complications*
  • Diabetes Insipidus / diagnosis
  • Diabetes Insipidus / metabolism
  • Empty Sella Syndrome / chemically induced*
  • Empty Sella Syndrome / diagnosis
  • Empty Sella Syndrome / metabolism
  • Female
  • Humans
  • Hypothalamic Diseases / complications*
  • Hypothalamic Diseases / diagnosis
  • Hypothalamic Diseases / metabolism
  • Leukemia, Erythroblastic, Acute / complications*
  • Leukemia, Erythroblastic, Acute / diagnosis
  • Leukemia, Erythroblastic, Acute / metabolism
  • MDS1 and EVI1 Complex Locus Protein
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pituitary Gland / pathology*
  • Proto-Oncogenes / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transforming Growth Factor beta1 / metabolism

Substances

  • DNA-Binding Proteins
  • MDS1 and EVI1 Complex Locus Protein
  • MECOM protein, human
  • Transcription Factors
  • Transforming Growth Factor beta1
  • Cholecalciferol